Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.67 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592620 | 0.87 | MAP4K1 (0.64) | MAP4K1MAP3K11CHEK1ATR | |
| SCHEMBL21592436 | 0.86 | MAP4K1 (0.64) | MAP4K1MAP3K11CHEK1JAK2CLK1 | |
| SCHEMBL21592624 | 0.85 | MAP4K1 (0.83) | MAP4K1CHEK1PRKD1ATRCLK1 | |
| SCHEMBL21592467 | 0.85 | MAP3K11 (0.60) | MAP4K1MAP3K11CLK1DYRK1A | |
| SCHEMBL21592553 | 0.85 | MAP4K1 (0.65) | MAP4K1MAP3K11CHEK1JAK2ATR | |
| SCHEMBL21592653 | 0.85 | MAP4K1 (0.72) | MAP4K1CHEK1PRKD1JAK2CLK1 | |
| SCHEMBL21592494 | 0.84 | MAP4K1 (0.81) | MAP4K1CHEK1PRKD1ATRCLK1 | |
| SCHEMBL21592435 | 0.83 | MAP4K1 (0.77) | MAP4K1CHEK1CLK1DYRK1AMAPK1 | |
| SCHEMBL28509578 | 0.82 | MAP4K1 (0.70) | MAP4K1CHEK1CLK1DYRK1AMAPK1 | |
| SCHEMBL21592754 | 0.82 | MAP4K1 (0.68) | MAP4K1CHEK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |