Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.62 |
| ▸ | TNIK | Q9UKE5 | 10/20 | 0.61 |
| ▸ | AXL | P30530 | 2/20 | 0.59 |
| ▸ | MERTK | Q12866 | 2/20 | 0.59 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592484 | 0.92 | MAP4K1 (0.61) | MAP4K1TNIKAXLMERTKMAP3K11 | |
| SCHEMBL21592435 | 0.86 | MAP4K1 (0.77) | MAP4K1TNIKAXLMERTK | |
| SCHEMBL21592502 | 0.83 | MAP4K1 (0.61) | MAP4K1TNIKAXLMERTKMAP3K11 | |
| SCHEMBL21592754 | 0.83 | MAP4K1 (0.68) | MAP4K1TNIKAXLMERTK | |
| SCHEMBL21592837 | 0.83 | TNIK (0.85) | MAP4K1TNIKMAP3K11IKBKBCHUK | |
| SCHEMBL21592719 | 0.81 | MAP4K1 (0.63) | MAP4K1TNIKAXLMERTKMAP3K11 | |
| SCHEMBL21592590 | 0.81 | MAP4K1 (0.61) | MAP4K1TNIKAXLMERTK | |
| SCHEMBL21592514 | 0.79 | MAP4K1 (0.63) | MAP4K1TNIKAXLMERTKJAK3 | |
| SCHEMBL21592591 | 0.79 | MAP4K1 (0.53) | MAP4K1AXLMERTKABL1FLT3 | |
| SCHEMBL21592700 | 0.79 | MAP4K1 (0.73) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |