Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.71 |
| ▸ | IL2 | P60568 | 5/20 | 0.71 |
| ▸ | CLK1 | P49759 | 1/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.62 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.62 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.60 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592486 | 0.90 | MAP4K1 (0.72) | MAP4K1IL2CLK1DYRK1ADYRK2 | |
| SCHEMBL21592423 | 0.90 | MAP4K1 (0.72) | MAP4K1IL2CLK1DYRK1ADYRK2 | |
| SCHEMBL21592450 | 0.90 | MAP4K1 (0.72) | MAP4K1IL2CLK1DYRK1ATNIK | |
| SCHEMBL21592503 | 0.89 | MAP4K1 (0.71) | MAP4K1IL2CLK1DYRK1ANTRK1 | |
| SCHEMBL21592477 | 0.89 | TNIK (0.74) | MAP4K1IL2MAP3K11TNIKKIT | |
| SCHEMBL28504588 | 0.88 | MAP4K1 (0.70) | MAP4K1IL2CLK1DYRK1ADYRK2 | |
| SCHEMBL21592574 | 0.87 | MAP4K1 (0.78) | MAP4K1IL2DYRK1AMAP3K11TNIK | |
| SCHEMBL21592506 | 0.87 | MAP4K1 (0.68) | MAP4K1IL2NTRK1MAP3K11TNIK | |
| SCHEMBL30938056 | 0.87 | MAP4K1 (0.71) | MAP4K1IL2CLK1DYRK1AMAP3K11 | |
| SCHEMBL29253626 | 0.87 | MAP4K1 (0.71) | MAP4K1IL2CLK1DYRK1AMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |