Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.78 |
| ▸ | IL2 | P60568 | 5/20 | 0.78 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592616 | 0.90 | MAP4K1 (0.65) | MAP4K1IL2MAP3K11LCKMAP4K3 | |
| SCHEMBL21592491 | 0.90 | MAP4K1 (0.75) | MAP4K1IL2MAP3K11KITTNIK | |
| SCHEMBL21592585 | 0.90 | MAP4K1 (0.69) | MAP4K1IL2MAP3K11TNIK | |
| SCHEMBL21592445 | 0.89 | MAP4K1 (0.78) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592466 | 0.89 | MAP4K1 (0.78) | MAP4K1IL2MAP3K11LCKMAP4K3 | |
| Hydrochloric Acid SCHEMBL28905282 | 0.89 | MAP4K1 (0.74) | MAP4K1IL2MAP3K11KITTNIK | |
| Hydrochloric Acid SCHEMBL28511021 | 0.89 | MAP4K1 (0.68) | MAP4K1IL2MAP3K11TNIK | |
| SCHEMBL21592492 | 0.89 | MAP4K1 (0.68) | MAP4K1IL2MAP3K11TNIK | |
| SCHEMBL21592423 | 0.88 | MAP4K1 (0.72) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592486 | 0.88 | MAP4K1 (0.72) | MAP4K1IL2MAP3K11DYRK1ATNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |