Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.59 |
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.48 |
| ▸ | WDR5 | P61964 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | IL2 | P60568 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592935 | 0.95 | MAP4K1 (0.58) | MAP4K1MAP3K11NTRK1TNIKKIT | |
| SCHEMBL21592725 | 0.92 | MAP4K1 (0.57) | MAP4K1MAP3K11NTRK1TNIKKIT | |
| SCHEMBL21592927 | 0.91 | MAP3K11 (0.57) | MAP4K1MAP3K11NTRK1TNIKKIT | |
| SCHEMBL21592765 | 0.91 | MAP4K1 (0.66) | MAP4K1MAP3K11NTRK1TNIKKIT | |
| SCHEMBL21592855 | 0.90 | MAP3K11 (0.56) | MAP4K1MAP3K11NTRK1TNIKKIT | |
| SCHEMBL21593022 | 0.90 | MAP4K1 (0.61) | MAP4K1MAP3K11TNIKIGF1RIL2 | |
| SCHEMBL21592455 | 0.90 | TNIK (0.57) | MAP4K1MAP3K11NTRK1TNIKKIT | |
| SCHEMBL21592687 | 0.90 | KIT (0.62) | MAP4K1MAP3K11NTRK1TNIKKIT | |
| SCHEMBL21592572 | 0.89 | MAP3K11 (0.64) | MAP4K1MAP3K11NTRK1TNIKKIT | |
| SCHEMBL21592783 | 0.89 | MAP3K11 (0.55) | MAP4K1MAP3K11NTRK1TNIKKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |