Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | IGF1R | P08069 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | WDR5 | P61964 | 3/20 | 0.50 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592927 | 0.90 | MAP3K11 (0.57) | MAP3K11NTRK1IGF1RKITWDR5 | |
| SCHEMBL21592787 | 0.89 | IGF1R (0.51) | MAP3K11NTRK1IGF1RWDR5MAP4K1 | |
| SCHEMBL21592777 | 0.89 | MAP4K1 (0.55) | MAP3K11IGF1RWDR5MAP4K1TNIK | |
| SCHEMBL21592565 | 0.89 | MAP4K1 (0.59) | MAP3K11NTRK1IGF1RKITWDR5 | |
| SCHEMBL21592989 | 0.89 | KIT (0.53) | MAP3K11NTRK1IGF1RKITWDR5 | |
| SCHEMBL21592811 | 0.88 | MAP4K1 (0.65) | MAP3K11IGF1RWDR5MAP4K1TNIK | |
| SCHEMBL21592855 | 0.87 | MAP3K11 (0.56) | MAP3K11NTRK1IGF1RKITWDR5 | |
| SCHEMBL21592687 | 0.87 | KIT (0.62) | MAP3K11NTRK1KITMAP4K1TNIK | |
| SCHEMBL21592455 | 0.87 | TNIK (0.57) | MAP3K11NTRK1IGF1RKITWDR5 | |
| SCHEMBL21592572 | 0.86 | MAP3K11 (0.64) | MAP3K11NTRK1IGF1RKITMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |