Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.75 |
| ▸ | IL2 | P60568 | 5/20 | 0.75 |
| ▸ | KIT | P10721 | 2/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.60 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.59 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.56 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28905282 | 0.99 | MAP4K1 (0.74) | MAP4K1IL2KITNTRK1MAP3K11 | |
| SCHEMBL21592574 | 0.90 | MAP4K1 (0.78) | MAP4K1IL2KITMAP3K11TNIK | |
| SCHEMBL21592450 | 0.87 | MAP4K1 (0.72) | MAP4K1IL2TNIKACVR1 | |
| SCHEMBL21592466 | 0.86 | MAP4K1 (0.78) | MAP4K1IL2MAP3K11TNIK | |
| SCHEMBL21592404 | 0.85 | MAP4K1 (0.67) | MAP4K1IL2MAP3K11TNIK | |
| SCHEMBL21592759 | 0.84 | MAP4K1 (0.79) | MAP4K1IL2KITMAP3K11TNIK | |
| SCHEMBL21592452 | 0.83 | MAP4K1 (0.84) | MAP4K1IL2KITMAP3K11 | |
| SCHEMBL8316940 | 0.83 | KIT (0.78) | KITNTRK1NEK1TNIK | |
| SCHEMBL15833893 | 0.83 | KIT (0.86) | KITNTRK1NEK1 | |
| SCHEMBL29253621 | 0.83 | DYRK1A (0.73) | MAP4K1IL2KITNTRK1NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |