Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 11/20 | 0.68 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | IL2 | P60568 | 3/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592724 | 0.90 | MAP4K1 (0.67) | MAP4K1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL21592624 | 0.86 | MAP4K1 (0.83) | MAP4K1MAPK1PIK3CAMTORPIK3CG | |
| SCHEMBL21592728 | 0.86 | MAP4K1 (0.55) | MAP4K1IL2MAP3K11 | |
| SCHEMBL21592649 | 0.85 | MAP4K1 (0.65) | MAP4K1SYKMAPK1JAK2JAK1 | |
| SCHEMBL21592699 | 0.83 | MAP4K1 (0.58) | MAP4K1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL21592965 | 0.83 | MAP4K1 (0.58) | MAP4K1MAPK1PIK3CAMTORPIK3CG | |
| SCHEMBL21592732 | 0.82 | MAP4K1 (0.64) | MAP4K1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL21592494 | 0.82 | MAP4K1 (0.81) | MAP4K1MAPK1ATR | |
| SCHEMBL21592714 | 0.81 | MAP4K1 (1.00) | MAP4K1IL2AXLMERTKMAPK1 | |
| SCHEMBL21592719 | 0.80 | MAP4K1 (0.63) | MAP4K1AXLMERTKMAPK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |