Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.58 |
| ▸ | MELK | Q14680 | 3/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 2/20 | 0.34 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592699 | 0.92 | MAP4K1 (0.58) | MAP4K1ATRIKBKBMAPK1PIK3CA | |
| SCHEMBL21592964 | 0.91 | MAP4K1 (0.52) | MAP4K1MELKTNIKMAPK1 | |
| SCHEMBL21592957 | 0.88 | MAP4K1 (0.56) | MAP4K1TNIKMAPK1PIK3CAMTOR | |
| SCHEMBL21592724 | 0.85 | MAP4K1 (0.67) | MAP4K1ATRMAP3K11TNIKMAPK1 | |
| SCHEMBL21592751 | 0.84 | MAP4K1 (0.55) | MAP4K1MELKATRMAP3K11MAPK1 | |
| SCHEMBL21592961 | 0.83 | MAP4K1 (0.44) | MAP4K1MELKMAPK1 | |
| SCHEMBL21592747 | 0.83 | MAP4K1 (0.68) | MAP4K1ATRMAP3K11MAPK1PIK3CA | |
| SCHEMBL21592624 | 0.81 | MAP4K1 (0.83) | MAP4K1ATRMAPK1PIK3CAMTOR | |
| SCHEMBL28512122 | 0.81 | MAP4K1 (0.45) | MAP4K1MELKMAPK1 | |
| SCHEMBL21592649 | 0.80 | MAP4K1 (0.65) | MAP4K1ATRMAP3K11TNIKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |