Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.59 |
| ▸ | HTR1D | P28221 | 7/20 | 0.44 |
| ▸ | HTR1B | P28222 | 7/20 | 0.44 |
| ▸ | HTR1F | P30939 | 7/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | IL2 | P60568 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21590218 | 0.82 | MAP4K1 (0.63) | MAP4K1CHEK1IL2RPS6KA3KDM4E | |
| SCHEMBL28906256 | 0.82 | MAP4K1 (0.63) | MAP4K1CHEK1IL2RPS6KA3KDM4E | |
| SCHEMBL28511089 | 0.81 | MAP4K1 (0.53) | MAP4K1CHEK1IL2RPS6KA3MAPK1 | |
| SCHEMBL21592615 | 0.79 | MAP4K1 (0.59) | MAP4K1CHEK1IL2RPS6KA3 | |
| SCHEMBL28504546 | 0.78 | MAP4K1 (0.70) | MAP4K1CHEK1IL2RPS6KA3KDM4E | |
| SCHEMBL14655414 | 0.78 | MAP4K1 (0.59) | MAP4K1CHEK1IL2RPS6KA3 | |
| SCHEMBL21592513 | 0.77 | MAPK1 (0.69) | MAP4K1CHEK1IL2MAPK1 | |
| SCHEMBL28509493 | 0.77 | MAP4K1 (0.69) | MAP4K1CHEK1IL2RPS6KA3KDM4E | |
| SCHEMBL21592750 | 0.77 | MAP4K1 (0.62) | MAP4K1CHEK1IL2RPS6KA3MAPK1 | |
| SCHEMBL21592474 | 0.77 | MAP4K1 (0.77) | MAP4K1IL2RPS6KA3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |