Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.63 |
| ▸ | IL2 | P60568 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28511089 | 0.90 | MAP4K1 (0.53) | MAP4K1IL2CHEK1RPS6KA3CLK1 | |
| SCHEMBL21590218 | 0.86 | MAP4K1 (0.63) | MAP4K1IL2CHEK1RPS6KA3KDM4E | |
| SCHEMBL28499887 | 0.85 | MAP4K1 (0.50) | MAP4K1MAPK1 | |
| SCHEMBL28507472 | 0.84 | MAP4K1 (0.49) | MAP4K1IL2MAPK1 | |
| SCHEMBL28506193 | 0.83 | TNIK (0.53) | MAP4K1MAPK1 | |
| SCHEMBL28506415 | 0.82 | MAP4K1 (0.46) | MAP4K1MAPK1 | |
| SCHEMBL21592748 | 0.82 | MAP4K1 (0.59) | MAP4K1IL2CHEK1RPS6KA3KDM4E | |
| SCHEMBL14655414 | 0.82 | MAP4K1 (0.59) | MAP4K1IL2CHEK1RPS6KA3CLK1 | |
| SCHEMBL28504546 | 0.82 | MAP4K1 (0.70) | MAP4K1IL2CHEK1RPS6KA3KDM4E | |
| SCHEMBL28504524 | 0.81 | MAP4K1 (0.46) | MAP4K1IL2CLK1DYRK1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |