Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.55 |
| ▸ | JAK2 | O60674 | 8/20 | 0.52 |
| ▸ | JAK1 | P23458 | 7/20 | 0.52 |
| ▸ | TYK2 | P29597 | 7/20 | 0.52 |
| ▸ | JAK3 | P52333 | 7/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592764 | 0.93 | MAP4K1 (0.52) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21592841 | 0.93 | MAP4K1 (0.53) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21592780 | 0.89 | MAP4K1 (0.52) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858770 | 0.86 | MAP4K1 (0.75) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922383 | 0.86 | MAP4K1 (0.51) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922382 | 0.86 | MAP4K1 (0.51) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21592836 | 0.86 | MAP4K1 (0.60) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21592955 | 0.85 | MAP4K1 (0.53) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21593058 | 0.85 | MAP4K1 (0.74) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL24722960 | 0.84 | JAK2 (0.48) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |