Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.74 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22922391 | 0.94 | MAP4K1 (0.68) | MAP4K1TNIKMAPK1JAK2JAK1 | |
| SCHEMBL21592719 | 0.92 | MAP4K1 (0.63) | MAP4K1TNIKMAPK1JAK2JAK1 | |
| SCHEMBL22922490 | 0.86 | MAP4K1 (0.58) | MAP4K1TNIKMAPK1JAK2JAK1 | |
| SCHEMBL21592752 | 0.86 | MAP4K1 (0.55) | MAP4K1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL21592732 | 0.86 | MAP4K1 (0.64) | MAP4K1TNIKMAPK1JAK2JAK1 | |
| SCHEMBL21592772 | 0.85 | MAP4K1 (0.55) | MAP4K1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL22858757 | 0.85 | MAP4K1 (1.00) | MAP4K1TNIKMAPK1JAK2JAK1 | |
| SCHEMBL29607707 | 0.85 | MAP4K1 (1.00) | MAP4K1TNIKMAPK1JAK2JAK1 | |
| SCHEMBL22858850 | 0.85 | MAP4K1 (0.88) | MAP4K1TNIKMAPK1JAK2JAK1 | |
| SCHEMBL29609216 | 0.85 | MAP4K1 (0.88) | MAP4K1TNIKMAPK1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |