Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.60 |
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.56 |
| ▸ | IL2 | P60568 | 1/20 | 0.56 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592482 | 0.90 | TNIK (0.59) | TNIKMAP4K1IL2MAP3K11CLK1 | |
| SCHEMBL21592464 | 0.90 | TNIK (0.64) | TNIKMAP4K1IL2MAP3K11CLK1 | |
| SCHEMBL28511324 | 0.89 | TNIK (0.61) | TNIKMAP4K1IL2MAP3K11CLK1 | |
| SCHEMBL21592540 | 0.86 | MAP4K1 (0.63) | TNIKMAP4K1IL2MAP3K11CLK1 | |
| SCHEMBL21592594 | 0.84 | MAP4K1 (0.63) | TNIKMAP4K1IL2MAP3K11CLK1 | |
| SCHEMBL21592768 | 0.84 | TNIK (0.57) | TNIKMAP4K1IL2MAP3K11CLK1 | |
| SCHEMBL21592566 | 0.82 | MAP4K1 (0.65) | TNIKMAP4K1IL2MAP3K11CYP3A4 | |
| SCHEMBL21592527 | 0.82 | MAP4K1 (0.63) | TNIKMAP4K1IL2MAP3K11CLK1 | |
| SCHEMBL21592760 | 0.81 | MAP4K1 (0.59) | TNIKMAP4K1IL2MAP3K11CLK1 | |
| SCHEMBL21592497 | 0.81 | SGK1 (0.68) | TNIKMAP4K1IL2MAP3K11CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |