Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.59 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.55 |
| ▸ | IL2 | P60568 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592768 | 0.90 | TNIK (0.57) | TNIKMAP4K1IL2CLK1DYRK1A | |
| SCHEMBL21592775 | 0.90 | TNIK (0.60) | TNIKMAP4K1IL2CLK1DYRK1A | |
| SCHEMBL21592464 | 0.89 | TNIK (0.64) | TNIKAXLMAP4K1IL2CLK1 | |
| SCHEMBL28511324 | 0.88 | TNIK (0.61) | TNIKAXLMAP4K1IL2CLK1 | |
| SCHEMBL21592540 | 0.86 | MAP4K1 (0.63) | TNIKMAP4K1IL2CLK1DYRK1A | |
| SCHEMBL21592594 | 0.84 | MAP4K1 (0.63) | TNIKMAP4K1IL2CLK1DYRK1A | |
| SCHEMBL21592733 | 0.82 | TNIK (0.58) | TNIKAXLMAP4K1IL2CLK1 | |
| SCHEMBL21592978 | 0.82 | MAP4K1 (0.59) | TNIKMAP4K1IL2CLK1DYRK1A | |
| SCHEMBL21592483 | 0.81 | MAP4K1 (0.64) | TNIKMAP4K1IL2CLK1DYRK1A | |
| SCHEMBL21592404 | 0.81 | MAP4K1 (0.67) | TNIKMAP4K1IL2MAP3K11RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |