Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.56 |
| ▸ | IL2 | P60568 | 4/20 | 0.56 |
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.55 |
| ▸ | KIT | P10721 | 2/20 | 0.50 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | WDR5 | P61964 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592687 | 0.91 | KIT (0.62) | MAP4K1IL2MAP3K11KITTNIK | |
| SCHEMBL21592833 | 0.90 | MAP4K1 (0.52) | MAP4K1IL2MAP3K11KITTNIK | |
| SCHEMBL21592726 | 0.88 | MAP4K1 (0.65) | MAP4K1IL2MAP3K11KITTNIK | |
| SCHEMBL21592692 | 0.86 | MAP4K1 (0.53) | MAP4K1IL2MAP3K11KITTNIK | |
| SCHEMBL21592858 | 0.86 | MAP4K1 (0.60) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592558 | 0.86 | MAP3K11 (0.63) | MAP4K1IL2MAP3K11TNIKDYRK1A | |
| SCHEMBL21592938 | 0.86 | MAP4K1 (0.63) | MAP4K1IL2MAP3K11TNIKDYRK1A | |
| SCHEMBL21593032 | 0.86 | MAP4K1 (0.63) | MAP4K1IL2MAP3K11TNIKDYRK1A | |
| SCHEMBL21593033 | 0.86 | MAP4K1 (0.63) | MAP4K1IL2MAP3K11TNIKDYRK1A | |
| SCHEMBL21592637 | 0.85 | MAP4K1 (0.59) | MAP4K1IL2MAP3K11KITTNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |