Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 11/20 | 0.52 |
| ▸ | IL2 | P60568 | 4/20 | 0.52 |
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.50 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592692 | 0.90 | MAP4K1 (0.53) | MAP4K1IL2MAP3K11TNIKKIT | |
| SCHEMBL21592829 | 0.90 | MAP4K1 (0.56) | MAP4K1IL2MAP3K11TNIKKIT | |
| SCHEMBL21592687 | 0.86 | KIT (0.62) | MAP4K1IL2MAP3K11TNIKKIT | |
| SCHEMBL21592726 | 0.85 | MAP4K1 (0.65) | MAP4K1IL2MAP3K11TNIKKIT | |
| SCHEMBL21592858 | 0.83 | MAP4K1 (0.60) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592792 | 0.82 | MAP4K1 (0.53) | MAP4K1IL2MAP3K11TNIKKIT | |
| SCHEMBL21592637 | 0.82 | MAP4K1 (0.59) | MAP4K1IL2MAP3K11TNIKKIT | |
| SCHEMBL21592994 | 0.82 | MAP3K11 (0.48) | MAP4K1IL2MAP3K11TNIKKIT | |
| SCHEMBL21592568 | 0.80 | MAP4K1 (0.56) | MAP4K1IL2MAP3K11TNIKDYRK1A | |
| SCHEMBL21592987 | 0.79 | MAP4K1 (0.55) | MAP4K1IL2MAP3K11TNIKDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |