Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 12/20 | 0.66 |
| ▸ | IL2 | P60568 | 7/20 | 0.66 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592853 | 0.86 | MAP4K1 (0.64) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592682 | 0.80 | MAP4K1 (0.60) | MAP4K1IL2MAP3K11 | |
| SCHEMBL28503252 | 0.79 | MAP4K1 (0.59) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592759 | 0.78 | MAP4K1 (0.79) | MAP4K1IL2MAP3K11KITAAK1 | |
| SCHEMBL21592707 | 0.77 | MAP4K1 (0.58) | MAP4K1IL2MAP3K11 | |
| SCHEMBL21592789 | 0.77 | KIT (0.60) | MAP4K1IL2MAP3K11KIT | |
| SCHEMBL21592574 | 0.77 | MAP4K1 (0.78) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592423 | 0.76 | MAP4K1 (0.72) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL28502462 | 0.76 | MAP4K1 (0.56) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592466 | 0.75 | MAP4K1 (0.78) | MAP4K1IL2MAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |