Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592896 | 0.91 | MAP4K1 (0.79) | MAP4K1NTRK1MAP3K11PIK3CGKIT | |
| SCHEMBL21592871 | 0.91 | MAP4K1 (0.63) | MAP4K1NTRK1AXLMAP3K11PIK3CG | |
| SCHEMBL21592735 | 0.87 | MAP4K1 (0.67) | MAP4K1AXLMAP3K11PIK3CGTNIK | |
| SCHEMBL21592854 | 0.84 | MAP4K1 (0.60) | MAP4K1AXLMAP3K11PIK3CGIGF1R | |
| SCHEMBL21592812 | 0.83 | MAP4K1 (0.81) | MAP4K1NTRK1MAP3K11PIK3CGIGF1R | |
| SCHEMBL21592765 | 0.83 | MAP4K1 (0.66) | MAP4K1NTRK1MAP3K11KITIGF1R | |
| SCHEMBL21592900 | 0.82 | MAP4K1 (0.66) | MAP4K1NTRK1MAP3K11KITTNIK | |
| SCHEMBL21592901 | 0.81 | MAP4K1 (0.75) | MAP4K1NTRK1MAP3K11PIK3CGIGF1R | |
| SCHEMBL21592803 | 0.80 | MAP4K1 (0.71) | MAP4K1NTRK1MAP3K11PIK3CGKIT | |
| SCHEMBL21592926 | 0.79 | MAP4K1 (0.78) | MAP4K1AXLMAP3K11PIK3CGTNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |