Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.63 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592901 | 0.91 | MAP4K1 (0.75) | MAP4K1MAP3K11IGF1RNTRK1PIK3CG | |
| SCHEMBL21592869 | 0.91 | MAP4K1 (0.66) | MAP4K1AXLMAP3K11IGF1RNTRK1 | |
| SCHEMBL21592735 | 0.85 | MAP4K1 (0.67) | MAP4K1AXLMAP3K11PIK3CGTNIK | |
| SCHEMBL24723493 | 0.84 | MAP4K1 (0.63) | MAP4K1MAP3K11IGF1RNTRK1PIK3CG | |
| SCHEMBL21592819 | 0.83 | MAP4K1 (0.75) | MAP4K1MAP3K11NTRK1PIK3CGTNIK | |
| SCHEMBL21592904 | 0.83 | MAP4K1 (0.62) | MAP4K1MAP3K11TNIK | |
| SCHEMBL21592854 | 0.82 | MAP4K1 (0.60) | MAP4K1AXLMAP3K11IGF1RPIK3CG | |
| SCHEMBL21592896 | 0.81 | MAP4K1 (0.79) | MAP4K1MAP3K11IGF1RNTRK1PIK3CG | |
| SCHEMBL21592838 | 0.81 | MAP4K1 (0.58) | MAP4K1MAP3K11JAK2 | |
| SCHEMBL21592807 | 0.80 | MAP4K1 (0.66) | MAP4K1MAP3K11PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |