Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.48 |
| ▸ | IL2 | P60568 | 1/20 | 0.47 |
| ▸ | SGK1 | O00141 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.46 |
| ▸ | SGK3 | Q96BR1 | 1/20 | 0.46 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592771 | 0.91 | MAP4K1 (0.56) | MAP4K1TNIKIL2SGK1DYRK1A | |
| SCHEMBL21593027 | 0.85 | MAP4K1 (0.59) | MAP4K1TNIKCAMKK2IL2SGK1 | |
| SCHEMBL21592757 | 0.84 | MAP4K1 (0.54) | MAP4K1TNIKCAMKK2IL2PIK3CG | |
| SCHEMBL21592888 | 0.83 | TNIK (0.49) | MAP4K1TNIKCAMKK2IL2SGK1 | |
| SCHEMBL21592884 | 0.83 | TNIK (0.49) | MAP4K1TNIKCAMKK2IL2SGK1 | |
| SCHEMBL21593056 | 0.81 | MAP4K1 (0.58) | MAP4K1TNIKCAMKK2IL2SGK1 | |
| SCHEMBL21592622 | 0.81 | MAP4K1 (0.59) | MAP4K1TNIKCAMKK2IL2PIK3CG | |
| SCHEMBL21592852 | 0.80 | MAP4K1 (0.60) | MAP4K1TNIKCAMKK2IL2PIK3CG | |
| SCHEMBL21592788 | 0.79 | MAP4K1 (0.58) | MAP4K1TNIKCAMKK2IL2SGK1 | |
| SCHEMBL21593030 | 0.79 | MAP4K1 (0.58) | MAP4K1TNIKCAMKK2IL2SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |