Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 8/20 | 0.49 |
| ▸ | SGK1 | O00141 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.49 |
| ▸ | SGK3 | Q96BR1 | 1/20 | 0.49 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.49 |
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | IL2 | P60568 | 1/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592888 | 1.00 | TNIK (0.49) | TNIKCAMKK2SGK1AURKACAMKK1 | |
| SCHEMBL21593026 | 0.93 | MAP4K1 (0.54) | TNIKCAMKK2SGK1AURKACAMKK1 | |
| SCHEMBL21593003 | 0.93 | MAP4K1 (0.54) | TNIKCAMKK2SGK1AURKACAMKK1 | |
| SCHEMBL21593007 | 0.93 | MAP4K1 (0.54) | TNIKCAMKK2SGK1AURKACAMKK1 | |
| SCHEMBL21592946 | 0.84 | MAP4K1 (0.67) | TNIKCAMKK2SGK1AURKACAMKK1 | |
| SCHEMBL21592968 | 0.84 | MAP4K1 (0.67) | TNIKCAMKK2SGK1AURKACAMKK1 | |
| SCHEMBL28499905 | 0.84 | MAP4K1 (0.67) | TNIKCAMKK2SGK1AURKACAMKK1 | |
| SCHEMBL21592943 | 0.84 | MAP4K1 (0.67) | TNIKCAMKK2SGK1AURKACAMKK1 | |
| SCHEMBL21592967 | 0.84 | MAP4K1 (0.67) | TNIKCAMKK2SGK1AURKACAMKK1 | |
| SCHEMBL28501998 | 0.83 | CAMKK2 (0.48) | CAMKK2SGK1AURKACAMKK1SGK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |