Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.57 |
| ▸ | IL2 | P60568 | 2/20 | 0.57 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.56 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.51 |
| ▸ | SGK1 | O00141 | 3/20 | 0.50 |
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593015 | 0.95 | TNIK (0.55) | MAP4K1IL2TNIKMAP3K11SGK1 | |
| SCHEMBL21593030 | 0.85 | MAP4K1 (0.58) | MAP4K1IL2TNIKMAP3K11SGK1 | |
| SCHEMBL21592948 | 0.84 | MAP4K1 (0.59) | MAP4K1IL2TNIKMAP3K11SGK1 | |
| SCHEMBL21593027 | 0.84 | MAP4K1 (0.59) | MAP4K1IL2TNIKMAP3K11SGK1 | |
| SCHEMBL21592945 | 0.84 | MAP4K1 (0.57) | MAP4K1IL2TNIKMAP3K11AXL | |
| SCHEMBL21592788 | 0.83 | MAP4K1 (0.58) | MAP4K1IL2TNIKMAP3K11SGK1 | |
| SCHEMBL21592581 | 0.82 | TNIK (0.57) | MAP4K1IL2TNIKMAP3K11SGK1 | |
| SCHEMBL21592577 | 0.82 | TNIK (0.57) | MAP4K1IL2TNIKMAP3K11SGK1 | |
| SCHEMBL21593024 | 0.82 | MAP4K1 (0.62) | MAP4K1IL2TNIKMAP3K11SGK1 | |
| SCHEMBL26145994 | 0.82 | MAP4K1 (0.60) | MAP4K1TNIKMAP3K11SGK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |