Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.57 |
| ▸ | IL2 | P60568 | 3/20 | 0.57 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.45 |
| ▸ | CLK1 | P49759 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592947 | 0.84 | MAP4K1 (0.57) | MAP4K1IL2TNIKMAP3K11PRKAB2 | |
| SCHEMBL21593015 | 0.79 | TNIK (0.55) | MAP4K1IL2TNIKMAP3K11AXL | |
| SCHEMBL22922573 | 0.77 | MAP4K1 (0.73) | MAP4K1TNIKMAP3K11 | |
| SCHEMBL21592868 | 0.76 | MAP4K1 (0.70) | MAP4K1IL2TNIKMAP3K11AXL | |
| SCHEMBL21593024 | 0.75 | MAP4K1 (0.62) | MAP4K1IL2TNIKMAP3K11AXL | |
| SCHEMBL28510111 | 0.75 | MAP4K1 (0.55) | MAP4K1IL2CLK1DYRK1ADYRK2 | |
| SCHEMBL21592948 | 0.74 | MAP4K1 (0.59) | MAP4K1IL2TNIKMAP3K11AXL | |
| SCHEMBL21592479 | 0.73 | MAP4K1 (0.64) | MAP4K1IL2TNIKCLK1DYRK1A | |
| SCHEMBL29204307 | 0.72 | MAP4K1 (0.64) | MAP4K1IL2TNIKDYRK1ADYRK1B | |
| SCHEMBL21592970 | 0.72 | MAP4K1 (0.64) | MAP4K1IL2TNIKCLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |