Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.67 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.40 |
| ▸ | SGK1 | O00141 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.40 |
| ▸ | SGK3 | Q96BR1 | 1/20 | 0.40 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28499905 | 1.00 | MAP4K1 (0.67) | MAP4K1TNIKPIK3CGMAP3K11CAMKK2 | |
| SCHEMBL21592968 | 1.00 | MAP4K1 (0.67) | MAP4K1TNIKPIK3CGMAP3K11CAMKK2 | |
| SCHEMBL21592946 | 1.00 | MAP4K1 (0.67) | MAP4K1TNIKPIK3CGMAP3K11CAMKK2 | |
| SCHEMBL21592943 | 1.00 | MAP4K1 (0.67) | MAP4K1TNIKPIK3CGMAP3K11CAMKK2 | |
| SCHEMBL21593026 | 0.90 | MAP4K1 (0.54) | MAP4K1TNIKPIK3CGMAP3K11CAMKK2 | |
| SCHEMBL21593007 | 0.90 | MAP4K1 (0.54) | MAP4K1TNIKPIK3CGMAP3K11CAMKK2 | |
| SCHEMBL21593003 | 0.90 | MAP4K1 (0.54) | MAP4K1TNIKPIK3CGMAP3K11CAMKK2 | |
| SCHEMBL21592884 | 0.84 | TNIK (0.49) | MAP4K1TNIKPIK3CGMAP3K11CAMKK2 | |
| SCHEMBL21592888 | 0.84 | TNIK (0.49) | MAP4K1TNIKPIK3CGMAP3K11CAMKK2 | |
| SCHEMBL21592634 | 0.82 | MAP4K1 (0.68) | MAP4K1TNIKPIK3CGMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |