Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.56 |
| ▸ | SGK1 | O00141 | 6/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 6/20 | 0.44 |
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592950 | 1.00 | MAP4K1 (0.56) | MAP4K1SGK1CAMKK2AXLMAP3K11 | |
| SCHEMBL21592891 | 0.84 | CAMKK2 (0.54) | MAP4K1SGK1CAMKK2AXLMAP3K11 | |
| SCHEMBL21592940 | 0.81 | MAP4K1 (0.61) | MAP4K1SGK1CAMKK2AXLMAP3K11 | |
| SCHEMBL21592634 | 0.79 | MAP4K1 (0.68) | MAP4K1MAP3K11PIK3CG | |
| SCHEMBL21592633 | 0.79 | MAP4K1 (0.68) | MAP4K1MAP3K11PIK3CG | |
| SCHEMBL21592845 | 0.79 | MAP4K1 (0.68) | MAP4K1MAP3K11PIK3CG | |
| SCHEMBL21592906 | 0.78 | MAP4K1 (0.75) | MAP4K1MAP3K11PIK3CG | |
| SCHEMBL21592913 | 0.78 | MAP4K1 (0.75) | MAP4K1MAP3K11PIK3CG | |
| SCHEMBL22922551 | 0.78 | MAP4K1 (0.53) | MAP4K1SGK1CAMKK2AXLMAP3K11 | |
| SCHEMBL22922550 | 0.78 | MAP4K1 (0.53) | MAP4K1SGK1CAMKK2AXLMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |