Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.68 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.42 |
| ▸ | IL2 | P60568 | 4/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592695 | 0.93 | MAP4K1 (0.56) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL21592944 | 0.87 | MAP4K1 (0.52) | MAP4K1 | |
| SCHEMBL21592926 | 0.86 | MAP4K1 (0.78) | MAP4K1MAP3K11TNIKIL2PIK3CG | |
| SCHEMBL21592809 | 0.85 | MAP4K1 (0.57) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL21592516 | 0.82 | MAP4K1 (0.59) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL21592717 | 0.82 | MAP4K1 (0.72) | MAP4K1MAP3K11TNIKPIK3CG | |
| SCHEMBL21592739 | 0.81 | MAP4K1 (1.00) | MAP4K1MAP3K11TNIKPIK3CG | |
| SCHEMBL31344455 | 0.80 | MAP4K1 (0.68) | MAP4K1TNIKIL2PIK3CG | |
| SCHEMBL21592812 | 0.80 | MAP4K1 (0.81) | MAP4K1MAP3K11TNIKIL2PIK3CG | |
| SCHEMBL28829874 | 0.80 | MAP4K1 (0.67) | MAP4K1TNIKIL2PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |