Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.57 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 7/20 | 0.49 |
| ▸ | IL2 | P60568 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592939 | 0.92 | MAP4K1 (0.56) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL21592695 | 0.92 | MAP4K1 (0.56) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL28906168 | 0.91 | MAP4K1 (0.56) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL21592507 | 0.89 | MAP4K1 (0.61) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL21592566 | 0.85 | MAP4K1 (0.65) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL21592984 | 0.85 | MAP4K1 (0.68) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL21592832 | 0.83 | MAP3K11 (0.54) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL21592852 | 0.83 | MAP4K1 (0.60) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL28499799 | 0.83 | SGK1 (0.63) | MAP4K1MAP3K11TNIKIL2 | |
| SCHEMBL21592569 | 0.82 | MAP4K1 (0.62) | MAP4K1MAP3K11TNIKIL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |