Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.43 |
| ▸ | CDK2 | P24941 | 5/20 | 0.43 |
| ▸ | CDK9 | P50750 | 5/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.43 |
| ▸ | IL2 | P60568 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28504378 | 0.91 | MAP4K1 (0.56) | MAP4K1TNIKDYRK1ACCNT1CCNA2 | |
| SCHEMBL21592665 | 0.85 | MAP4K1 (0.55) | MAP4K1TNIKDYRK1AMAP3K11IL2 | |
| SCHEMBL21592647 | 0.85 | MAP4K1 (0.62) | MAP4K1TNIKMAP3K11IL2 | |
| SCHEMBL21592622 | 0.84 | MAP4K1 (0.59) | MAP4K1TNIKMAP3K11IL2 | |
| SCHEMBL28502217 | 0.82 | MAP4K1 (0.59) | MAP4K1TNIKMAP3K11IL2 | |
| SCHEMBL21592889 | 0.82 | MAP4K1 (0.57) | MAP4K1TNIKDYRK1AMAP3K11IL2 | |
| SCHEMBL21592549 | 0.82 | MAP4K1 (0.53) | MAP4K1TNIKDYRK1AMAP3K11IL2 | |
| SCHEMBL21592934 | 0.80 | MAP4K1 (0.58) | MAP4K1TNIKDYRK1AIL2 | |
| SCHEMBL21592893 | 0.80 | MAP4K1 (0.57) | MAP4K1TNIK | |
| SCHEMBL21592631 | 0.80 | MAP4K1 (0.57) | MAP4K1TNIKMAP3K11IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |