Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.44 |
| ▸ | CDK2 | P24941 | 6/20 | 0.44 |
| ▸ | CDK9 | P50750 | 6/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.44 |
| ▸ | IL2 | P60568 | 3/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593047 | 0.91 | MAP4K1 (0.54) | MAP4K1DYRK1ACCNT1CCNA2CDK2 | |
| SCHEMBL28502252 | 0.84 | MAP4K1 (0.65) | MAP4K1CAMKK2MAP3K11IL2TNIK | |
| SCHEMBL28511323 | 0.81 | MAP4K1 (0.55) | MAP4K1DYRK1ACAMKK2CDK2MAP3K11 | |
| Hydrochloric Acid SCHEMBL28507116 | 0.80 | MAP4K1 (0.54) | MAP4K1DYRK1ACAMKK2MAP3K11IL2 | |
| SCHEMBL28511448 | 0.79 | MAP4K1 (0.63) | MAP4K1CAMKK2MAP3K11IL2TNIK | |
| SCHEMBL21592665 | 0.79 | MAP4K1 (0.55) | MAP4K1DYRK1ACAMKK2MAP3K11IL2 | |
| SCHEMBL21592647 | 0.78 | MAP4K1 (0.62) | MAP4K1CAMKK2MAP3K11IL2TNIK | |
| SCHEMBL21592622 | 0.78 | MAP4K1 (0.59) | MAP4K1CAMKK2MAP3K11IL2TNIK | |
| SCHEMBL28504384 | 0.77 | MAP4K1 (0.66) | MAP4K1CDK2MAP3K11IL2TNIK | |
| SCHEMBL21593022 | 0.77 | MAP4K1 (0.61) | MAP4K1DYRK1ACAMKK2MAP3K11IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |