Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.57 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22922565 | 0.89 | MAP4K1 (0.56) | MAP4K1MAP3K11TNIKPIK3CGDYRK1B | |
| SCHEMBL21593053 | 0.88 | MAP4K1 (0.58) | MAP4K1MAP3K11TNIKPIK3CGAAK1 | |
| SCHEMBL21592873 | 0.87 | MAP4K1 (0.59) | MAP4K1MAP3K11TNIKPIK3CG | |
| SCHEMBL28597585 | 0.85 | MAP4K1 (0.55) | MAP4K1MAP3K11TNIKPIK3CG | |
| SCHEMBL28591609 | 0.85 | MAP4K1 (0.55) | MAP4K1MAP3K11TNIKPIK3CG | |
| SCHEMBL28591607 | 0.85 | MAP4K1 (0.55) | MAP4K1MAP3K11TNIKPIK3CG | |
| SCHEMBL21592850 | 0.85 | MAP4K1 (0.58) | MAP4K1MAP3K11TNIK | |
| SCHEMBL21592762 | 0.84 | MAP4K1 (0.64) | MAP4K1MAP3K11TNIKPIK3CG | |
| SCHEMBL29869055 | 0.84 | MAP4K1 (0.77) | MAP4K1MAP3K11TNIKPIK3CGDYRK1B | |
| SCHEMBL29869158 | 0.84 | MAP4K1 (0.77) | MAP4K1MAP3K11TNIKPIK3CGDYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |