Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.56 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593049 | 0.89 | MAP4K1 (0.57) | MAP4K1MAP3K11TNIKDYRK1BPIK3CG | |
| SCHEMBL22922397 | 0.88 | MAP4K1 (0.53) | MAP4K1MAP3K11TNIKDYRK1B | |
| SCHEMBL29869158 | 0.86 | MAP4K1 (0.77) | MAP4K1MAP3K11TNIKDYRK1BPIK3CG | |
| SCHEMBL22922392 | 0.86 | MAP4K1 (0.77) | MAP4K1MAP3K11TNIKDYRK1BPIK3CG | |
| SCHEMBL29869145 | 0.86 | MAP4K1 (0.77) | MAP4K1MAP3K11TNIKDYRK1BPIK3CG | |
| SCHEMBL22922484 | 0.86 | MAP4K1 (0.77) | MAP4K1MAP3K11TNIKDYRK1BPIK3CG | |
| SCHEMBL22922393 | 0.86 | MAP4K1 (0.77) | MAP4K1MAP3K11TNIKDYRK1BPIK3CG | |
| SCHEMBL22922488 | 0.86 | MAP4K1 (0.77) | MAP4K1MAP3K11TNIKDYRK1BPIK3CG | |
| SCHEMBL29869055 | 0.86 | MAP4K1 (0.77) | MAP4K1MAP3K11TNIKDYRK1BPIK3CG | |
| SCHEMBL29869247 | 0.86 | MAP4K1 (0.77) | MAP4K1MAP3K11TNIKDYRK1BPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021013083-A1 | TRICYCLIC COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-28 | — | — | WO | disclosed |