Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MERTK | Q12866 | 9/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 8/20 | 0.44 |
| ▸ | AXL | P30530 | 5/20 | 0.44 |
| ▸ | FLT3 | P36888 | 5/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 5/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5177285 | 0.87 | KMT2A (0.61) | KMT2AAXLADORA1ADORA3 | |
| SCHEMBL20330322 | 0.83 | KMT2A (0.45) | KMT2AAXLMAPK8MAPK9MAPK3 | |
| SCHEMBL20329963 | 0.83 | MAPK1 (0.48) | KMT2ATYRO3AXLMAPK3 | |
| SCHEMBL21593676 | 0.83 | KMT2A (0.47) | KMT2AMERTKTYRO3AXLFLT3 | |
| SCHEMBL21593661 | 0.82 | KMT2A (0.49) | KMT2AMERTKTYRO3AXLFLT3 | |
| SCHEMBL21593667 | 0.82 | KMT2A (0.46) | KMT2AAXLADORA1ADORA3MAPK3 | |
| SCHEMBL16429050 | 0.80 | KMT2A (0.47) | KMT2AMERTKTYRO3AXLFLT3 | |
| SCHEMBL16429049 | 0.80 | KMT2A (0.47) | KMT2AMERTKTYRO3AXLFLT3 | |
| SCHEMBL13649033 | 0.79 | KMT2A (0.49) | KMT2AMERTKTYRO3AXLFLT3 | |
| SCHEMBL16438333 | 0.79 | KMT2A (0.49) | KMT2AMERTKTYRO3AXLFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238929-A1 | PURINONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-12-19 | — | — | WO | disclosed |