Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LATS1 | O95835 | 3/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | SMO | Q99835 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593630 | 0.85 | KMT2A (0.33) | KMT2ALATS1LATS2AXLMAPK8 | |
| SCHEMBL21593590 | 0.84 | KMT2A (0.33) | KMT2ALATS1LATS2CHRM4AXL | |
| SCHEMBL20330481 | 0.82 | MAPK8 (0.37) | KMT2ALATS1LATS2MAPK8MAPK9 | |
| SCHEMBL21593670 | 0.81 | AURKA (0.33) | KMT2ALATS1LATS2 | |
| SCHEMBL20329968 | 0.79 | SYK (0.46) | KMT2A | |
| SCHEMBL30736504 | 0.79 | SYK (0.46) | KMT2A | |
| SCHEMBL21593661 | 0.75 | KMT2A (0.49) | KMT2AGSK3AGSK3BAXLMAPK8 | |
| SCHEMBL28313531 | 0.73 | GNRHR (0.34) | LATS1LATS2 | |
| SCHEMBL25812072 | 0.71 | LATS1 (0.35) | KMT2ALATS1LATS2CHRM4 | |
| SCHEMBL17168786 | 0.70 | LATS1 (0.36) | KMT2ALATS1LATS2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238929-A1 | PURINONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-12-19 | — | — | WO | disclosed |