Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20329968 | 1.00 | SYK (0.46) | SYKMAPTNR2F2NPSR1KDM4E | |
| SCHEMBL20330481 | 0.84 | MAPK8 (0.37) | KMT2ANFKB1NFKB2RELAJUN | |
| SCHEMBL30736374 | 0.81 | NR2F2 (0.53) | SYKMAPTNR2F2NPSR1KDM4E | |
| SCHEMBL20299341 | 0.81 | NR2F2 (0.53) | SYKMAPTNR2F2NPSR1KDM4E | |
| SCHEMBL20329838 | 0.81 | NR2F2 (0.53) | SYKMAPTNR2F2NPSR1KDM4E | |
| SCHEMBL23452672 | 0.81 | NR2F2 (0.53) | SYKMAPTNR2F2NPSR1KDM4E | |
| SCHEMBL31612079 | 0.80 | SYK (0.49) | SYKMAPTNR2F2NPSR1KDM4E | |
| SCHEMBL24852041 | 0.80 | SYK (0.49) | SYKMAPTNR2F2NPSR1KDM4E | |
| SCHEMBL21593637 | 0.79 | KMT2A (0.34) | KMT2A | |
| SCHEMBL23452637 | 0.78 | NR2F2 (0.50) | SYKMAPTNR2F2NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112236431-B | Purinone Compounds and Their Use in the Treatment of Cancer | 阿斯利康(瑞典)有限公司 | 2024-02-13 | — | — | CN | disclosed |