Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21591870 | 1.00 | MEN1 (0.42) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL21591869 | 1.00 | MEN1 (0.42) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL23452666 | 0.91 | USP30 (0.46) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL21591923 | 0.88 | SYK (0.47) | MEN1KMT2AHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL30736455 | 0.88 | SYK (0.47) | MEN1KMT2AHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL31756147 | 0.88 | USP30 (0.39) | HPGDUSP30BTKPOLBCDK4 | |
| SCHEMBL31756059 | 0.88 | USP30 (0.39) | HPGDUSP30BTKPOLBCDK4 | |
| SCHEMBL21593725 | 0.87 | USP30 (0.38) | HPGDUSP30BTKCDK4CCND1 | |
| SCHEMBL21593643 | 0.86 | BTK (0.51) | MEN1KMT2AUSP2HPGDNPSR1 | |
| SCHEMBL21593611 | 0.86 | BTK (0.51) | MEN1KMT2AUSP2HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238929-A1 | PURINONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-12-19 | — | — | WO | disclosed |