Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | AXL | P30530 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.38 |
| ▸ | MERTK | Q12866 | 3/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28313535 | 0.89 | KMT2A (0.62) | KMT2AAXLADORA3PDE4AADORA2A | |
| SCHEMBL21593660 | 0.86 | KMT2A (0.44) | KMT2AAXLFLT3TYRO3MERTK | |
| SCHEMBL21593664 | 0.85 | KMT2A (0.43) | KMT2AAXLADORA3FLT3TYRO3 | |
| SCHEMBL6424706 | 0.81 | KMT2A (0.60) | KMT2AAXLADORA3ADORA2AADORA1 | |
| SCHEMBL21593571 | 0.78 | KMT2A (0.68) | KMT2AAXLPDE4APDE4BPDE4C | |
| SCHEMBL1937546 | 0.77 | KMT2A (0.71) | KMT2AAXLADORA3PDE4AADORA2A | |
| SCHEMBL22348506 | 0.77 | KMT2A (0.55) | KMT2AAXLADORA3ADORA2AADORA1 | |
| SCHEMBL2816614 | 0.76 | KMT2A (0.51) | KMT2AAXLADORA3ADORA2AADORA1 | |
| SCHEMBL13812813 | 0.76 | KMT2A (0.65) | KMT2AAXLADORA3PDE4APDE4B | |
| SCHEMBL1934159 | 0.76 | KMT2A (0.69) | KMT2AAXLADORA3PDE4AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238929-A1 | PURINONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-12-19 | — | — | WO | disclosed |