Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593677 | 0.85 | KMT2A (0.59) | KMT2AAXLADORA3ADORA2AADORA1 | |
| SCHEMBL21593660 | 0.83 | KMT2A (0.44) | KMT2AAXLFLT3TYRO3MERTK | |
| SCHEMBL21593667 | 0.77 | KMT2A (0.46) | KMT2AAXLADORA3ADORA2AADORA1 | |
| SCHEMBL13649056 | 0.77 | KMT2A (0.48) | KMT2AAXLADORA3ADORA2AADORA1 | |
| SCHEMBL28313535 | 0.77 | KMT2A (0.62) | KMT2AAXLADORA3ADORA2AADORA1 | |
| SCHEMBL21593576 | 0.77 | KMT2A (0.48) | KMT2AAXLADORA3ADORA2AADORA1 | |
| SCHEMBL20330316 | 0.76 | KMT2A (0.47) | KMT2AAXLADORA3ADORA2AADORA1 | |
| SCHEMBL30736404 | 0.75 | NR2F2 (0.52) | KMT2AMEN1 | |
| SCHEMBL20299337 | 0.75 | NR2F2 (0.52) | KMT2AMEN1 | |
| SCHEMBL26179066 | 0.75 | MAPK1 (0.47) | KMT2AAXLFLT3TYRO3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238929-A1 | PURINONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-12-19 | — | — | WO | disclosed |