Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21595372 | 0.82 | GRIN2B (0.39) | FAAH | |
| SCHEMBL21595458 | 0.80 | ELANE (0.45) | — | |
| SCHEMBL21595424 | 0.74 | MEN1 (0.34) | — | |
| SCHEMBL21595440 | 0.71 | ELANE (0.44) | — | |
| SCHEMBL21595277 | 0.69 | FAAH (0.37) | FAAH | |
| SCHEMBL15751177 | 0.66 | SCD (0.33) | — | |
| SCHEMBL29998084 | 0.66 | HCRTR1 (0.31) | — | |
| SCHEMBL30893978 | 0.66 | HCRTR1 (0.31) | — | |
| SCHEMBL5597540 | 0.64 | FAAH (0.51) | FAAH | |
| SCHEMBL22409351 | 0.64 | SOS1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810615-A1 | ARGINASE INHIBITORS AND METHODS OF USE | Merck Sharp & Dohme Corp. (US) | 2021-04-28 | — | — | EP | disclosed |
| WO-2019245890-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2019-12-26 | — | — | WO | disclosed |