Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.74 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30763162 | 1.00 | HDAC3 (0.74) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL31734120 | 0.85 | HDAC3 (1.00) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL18064956 | 0.85 | HDAC3 (1.00) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL5285570 | 0.84 | HDAC3 (0.71) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL30763136 | 0.84 | HDAC3 (0.71) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL18064949 | 0.83 | MCL1 (0.73) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4763131 | 0.82 | HTT (0.62) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL21595563 | 0.82 | KMT2A (0.54) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL14825158 | 0.82 | MCL1 (0.71) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL28270381 | 0.82 | MCL1 (0.71) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810597-B1 | 1,2,4-TRIAZOLE DERIVATIVES AS TANKYRASE INHIBITORS | UNIV OSLO HF (NO) | 2025-11-26 | — | — | EP | disclosed |
| US-11926614-B2 | 1,2,4-triazole derivatives as tankyrase inhibitors | OSLO UNIVERSITETSSYKEHUS HF (NO) | 2024-03-12 | — | — | US | disclosed |
| CN-112469714-B | 1,2, 4-triazole derivatives as tankyrase inhibitors | 奥斯陆大学国家医院 | 2024-03-01 | — | — | CN | disclosed |
| EP-3810597-A1 | 1,2,4-TRIAZOLE DERIVATIVES AS TANKYRASE INHIBITORS | Oslo Universitetssykehus HF (NO) | 2021-04-28 | — | — | EP | disclosed |
| WO-2019243822-A1 | 1,2,4-TRIAZOLE DERIVATIVES AS TANKYRASE INHIBITORS | OSLO UNIVERSITETSSYKEHUS HF (NO) | 2019-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11926614-B2 | 1,2,4-triazole derivatives as tankyrase inhibitors | GBA3, CBR3, TECR | HDAC3 1635/4885HDAC1 2788/4885HDAC2 3026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.