Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18086518 | 0.89 | HDAC3 (0.67) | HTTSMN1; SMN2KDM4EHDAC3HDAC1 | |
| SCHEMBL10415432 | 0.82 | GRM4 (0.63) | HTTSMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL30763162 | 0.82 | HDAC3 (0.74) | HTTSMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL21595522 | 0.82 | HDAC3 (0.74) | HTTSMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL4479064 | 0.78 | ROCK2 (0.57) | HTTSMN1; SMN2KDM4EKMT2AALOX15 | |
| SCHEMBL12010995 | 0.77 | RAB9A (0.64) | HTTSMN1; SMN2MEN1KMT2ACTDSP1 | |
| SCHEMBL29393380 | 0.77 | GAA (0.76) | SMN1; SMN2HDAC3HDAC1HDAC2NPC1 | |
| SCHEMBL4483530 | 0.77 | THRB (0.53) | HTTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14062228 | 0.77 | GAA (0.76) | SMN1; SMN2HDAC3HDAC1HDAC2NPC1 | |
| SCHEMBL28075797 | 0.77 | GSK3A (0.66) | HTTSMN1; SMN2KDM4EHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937682-A1 | MET KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007041379-A1 | MET KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-12 | — | — | WO | disclosed |