Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.62 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | BTK | Q06187 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600951 | 0.87 | EGFR (0.57) | EGFRJAK3BTK | |
| SCHEMBL21596405 | 0.84 | CDK1 (0.59) | EGFRCDK1KDRJAK3 | |
| SCHEMBL30379340 | 0.84 | CDK1 (0.59) | EGFRCDK1KDRJAK3 | |
| SCHEMBL28532418 | 0.84 | CDK1 (0.54) | EGFRCDK1KDRJAK3 | |
| SCHEMBL30379421 | 0.84 | CDK1 (0.54) | EGFRCDK1KDRJAK3 | |
| SCHEMBL21596346 | 0.82 | CDK1 (0.55) | EGFRCDK1KDRJAK3 | |
| SCHEMBL30380205 | 0.82 | CDK1 (0.55) | EGFRCDK1KDRJAK3 | |
| SCHEMBL22518395 | 0.81 | EGFR (0.75) | EGFRJAK3BTK | |
| SCHEMBL21600950 | 0.81 | JAK3 (0.55) | EGFRJAK3 | |
| SCHEMBL21600914 | 0.80 | JAK3 (0.54) | EGFRKDRJAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |