Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 9/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600951 | 0.93 | EGFR (0.57) | JAK3MAP3K7SRCFGFR1MAPK1 | |
| SCHEMBL21600914 | 0.90 | JAK3 (0.54) | JAK3MAPK3MAP3K7SRCFGFR1 | |
| SCHEMBL21596307 | 0.89 | JAK3 (0.64) | JAK3MAP3K7SRCFGFR1MAPK1 | |
| SCHEMBL21601021 | 0.85 | MAP3K7 (0.59) | JAK3MAPK3MAP3K7SRCFGFR1 | |
| SCHEMBL21600766 | 0.84 | FGFR1 (0.54) | JAK3MAPK3MAP3K7SRCFGFR1 | |
| SCHEMBL21600812 | 0.83 | JAK3 (0.56) | JAK3MAPK3MAP3K7SRCFGFR1 | |
| SCHEMBL21894147 | 0.82 | MAPK3 (0.74) | MAPK3MAP3K7SRCFGFR1MAPK1 | |
| SCHEMBL21600807 | 0.81 | JAK3 (0.54) | JAK3MAPK3MAP3K7SRCFGFR1 | |
| SCHEMBL23607010 | 0.81 | PLK1 (0.60) | JAK3MAPK3SRCFGFR1EGFR | |
| SCHEMBL30043589 | 0.81 | PLK1 (0.60) | JAK3MAPK3SRCFGFR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |