Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.42 |
| ▸ | PLK1 | P53350 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21596379 | 0.87 | PLK1 (0.56) | MAPK3LRRK2PLK1ALKFGFR1 | |
| SCHEMBL21600782 | 0.86 | ALK (0.49) | MAPK3ALKIGF1RCDK2 | |
| SCHEMBL21596373 | 0.82 | MAPK3 (0.47) | MAPK3JAK3LRRK2PLK1ALK | |
| SCHEMBL21600829 | 0.81 | MAPK3 (0.46) | MAPK3JAK3LRRK2PLK1ALK | |
| SCHEMBL21600908 | 0.81 | JAK3 (0.51) | MAPK3JAK3PLK1FGFR4TTK | |
| SCHEMBL21596388 | 0.81 | MAPK3 (0.44) | MAPK3JAK3LRRK2PLK1ALK | |
| SCHEMBL21600933 | 0.81 | FGFR1 (0.43) | MAPK3JAK3LRRK2ALKFGFR1 | |
| SCHEMBL21596348 | 0.80 | ALK (0.54) | MAPK3JAK3LRRK2PLK1ALK | |
| SCHEMBL21600801 | 0.79 | MAPK3 (0.44) | MAPK3JAK3LRRK2PLK1ALK | |
| SCHEMBL30379995 | 0.78 | ALK (0.52) | MAPK3JAK3LRRK2PLK1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |