Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 9/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.53 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21596347 | 0.88 | PLK1 (0.56) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21596358 | 0.87 | MAPK3 (0.47) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28537291 | 0.83 | PLK1 (0.63) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28546192 | 0.83 | PLK1 (0.57) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21600782 | 0.82 | ALK (0.49) | MAPK3ALK | |
| SCHEMBL21600982 | 0.80 | EGFR (0.58) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21600965 | 0.78 | JAK3 (0.60) | FGFR1FGFR4MAPK3TTKEGFR | |
| SCHEMBL21596373 | 0.77 | MAPK3 (0.47) | PLK1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21600829 | 0.77 | MAPK3 (0.46) | PLK1FGFR1MAPK3LRRK2EGFR | |
| SCHEMBL23606892 | 0.76 | MAPK10 (0.48) | PLK1FGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |