Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.40 |
| ▸ | TTK | P33981 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30380081 | 1.00 | MAPK10 (0.46) | MAPK10CHEK1CHEK2PIK3CACTSL | |
| SCHEMBL21599131 | 0.92 | MAPK10 (0.44) | MAPK10CHEK1CHEK2CTSLCTSS | |
| SCHEMBL30379621 | 0.92 | MAPK10 (0.44) | MAPK10CHEK1CHEK2CTSLCTSS | |
| SCHEMBL28536928 | 0.90 | MAPK10 (0.46) | MAPK10CHEK1CHEK2PIK3CACTSL | |
| SCHEMBL21600833 | 0.88 | MAPK10 (0.42) | MAPK10CHEK1CHEK2PIK3CACTSL | |
| SCHEMBL28909341 | 0.87 | SLC2A1 (0.46) | MAPK10CHEK1CHEK2PIK3CACTSL | |
| SCHEMBL30379338 | 0.87 | SLC2A1 (0.46) | MAPK10CHEK1CHEK2PIK3CACTSL | |
| SCHEMBL21596364 | 0.81 | CTSC (0.47) | PIK3CACTSLJAK3FGFR1 | |
| SCHEMBL30380067 | 0.81 | CTSC (0.47) | PIK3CACTSLJAK3FGFR1 | |
| SCHEMBL28533099 | 0.81 | MAPK10 (0.45) | MAPK10CHEK1CHEK2CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |