Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 5/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.40 |
| ▸ | CCND1 | P24385 | 4/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCND3 | P30281 | 2/20 | 0.38 |
| ▸ | CCNH | P51946 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28536928 | 0.91 | MAPK10 (0.46) | MAPK10JAK2JAK3JAK1PRKCQ | |
| SCHEMBL30379741 | 0.91 | JAK2 (0.44) | MAPK10JAK2JAK3JAK1PRKCQ | |
| SCHEMBL28533599 | 0.91 | JAK2 (0.44) | MAPK10JAK2JAK3JAK1PRKCQ | |
| SCHEMBL21599131 | 0.90 | MAPK10 (0.44) | MAPK10JAK2JAK3JAK1PRKCQ | |
| SCHEMBL30379621 | 0.90 | MAPK10 (0.44) | MAPK10JAK2JAK3JAK1PRKCQ | |
| SCHEMBL21596399 | 0.85 | FGFR4 (0.51) | JAK3FGFR1 | |
| SCHEMBL30379371 | 0.85 | FGFR4 (0.51) | JAK3FGFR1 | |
| SCHEMBL21600802 | 0.85 | MAPK10 (0.40) | MAPK10JAK2JAK3JAK1PRKCQ | |
| SCHEMBL30379338 | 0.82 | SLC2A1 (0.46) | MAPK10JAK2JAK3JAK1PRKCQ | |
| SCHEMBL28909341 | 0.82 | SLC2A1 (0.46) | MAPK10JAK2JAK3JAK1PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |