Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28607607 | 0.91 | KDM4E (0.53) | KMT2AMAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL28607611 | 0.91 | KDM4E (0.53) | KMT2AMAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL28611808 | 0.90 | KMT2A (0.51) | KMT2AMAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL21603914 | 0.89 | KDM4E (0.70) | KMT2AMAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL28618673 | 0.89 | KDM4E (0.70) | KMT2AMAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL28610544 | 0.88 | KDM4E (0.57) | KMT2AMAPTALDH1A1HPGDKDM4E | |
| SCHEMBL21597701 | 0.88 | MAPT (0.51) | KMT2AMAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL21597710 | 0.88 | KDM4E (0.69) | KMT2AMAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL28610613 | 0.87 | MAPT (0.55) | KMT2AMAPTALDH1A1HPGDKDM4E | |
| SCHEMBL28610570 | 0.87 | KDM4E (0.52) | KMT2AMAPTALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810606-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2021-04-28 | — | — | EP | disclosed |
| CN-112566910-A | Thiophene derivatives for the treatment of IgE induced diseases | UCB生物制药有限责任公司 | 2021-03-26 | — | — | CN | disclosed |
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |