Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18878793 | 0.80 | SIGMAR1 (0.45) | SIGMAR1GAAOPRD1OPRM1KDM4E | |
| SCHEMBL21081224 | 0.71 | SIGMAR1 (0.47) | SIGMAR1GAAOPRD1OPRM1KDM4E | |
| SCHEMBL21173102 | 0.71 | SIGMAR1 (0.47) | SIGMAR1GAAOPRD1OPRM1KDM4E | |
| SCHEMBL19791308 | 0.68 | GAA (0.41) | GAAOPRD1OPRM1KDM4ECYP3A4 | |
| SCHEMBL18994724 | 0.67 | GAA (0.67) | GAAOPRD1OPRM1KDM4ECYP3A4 | |
| SCHEMBL24538638 | 0.67 | GAA (0.72) | SIGMAR1GAAOPRD1OPRM1KDM4E | |
| SCHEMBL19199626 | 0.67 | GAA (0.72) | SIGMAR1GAAOPRD1OPRM1KDM4E | |
| SCHEMBL18229424 | 0.67 | GAA (0.72) | SIGMAR1GAAOPRD1OPRM1KDM4E | |
| SCHEMBL16444908 | 0.67 | GAA (0.72) | SIGMAR1GAAOPRD1OPRM1KDM4E | |
| SCHEMBL19199908 | 0.64 | GAA (0.54) | GAAOPRD1OPRM1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004114-B1 | MORPHAN AND MORPHINAN ANALOGUES, AND METHODS OF USE | ALKERMES PHARMA IRELAND LTD (IE) | 2019-12-25 | — | — | EP | disclosed |