Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 11/20 | 0.55 |
| ▸ | SRC | P12931 | 5/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30379294 | 1.00 | MAPK3 (0.55) | MAPK3SRCMAP3K7FGFR1MAPK1 | |
| SCHEMBL21600760 | 0.91 | JAK3 (0.51) | MAPK3SRCMAP3K7FGFR1MAPK1 | |
| SCHEMBL21600759 | 0.89 | IGF1R (0.51) | MAPK3SRCMAP3K7FGFR1MAPK1 | |
| SCHEMBL25140070 | 0.89 | JAK3 (0.54) | MAPK3SRCMAP3K7FGFR1MAPK1 | |
| SCHEMBL21600915 | 0.87 | JAK3 (0.49) | MAPK3MAP3K7FGFR1MAP2K1JAK3 | |
| SCHEMBL21600812 | 0.87 | JAK3 (0.56) | MAPK3SRCMAP3K7FGFR1MAPK1 | |
| SCHEMBL21600754 | 0.86 | JAK3 (0.52) | MAPK3MAP3K7FGFR1MAP2K1JAK3 | |
| SCHEMBL21600786 | 0.86 | MAPK3 (0.52) | MAPK3MAP3K7FGFR1MAP2K1JAK3 | |
| SCHEMBL30379585 | 0.86 | MAPK3 (0.52) | MAPK3MAP3K7FGFR1MAP2K1JAK3 | |
| SCHEMBL23606837 | 0.86 | JAK3 (0.51) | MAPK3SRCMAP3K7FGFR1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |